DNA Computing and Informatics at Surfaces

Robert M. Corn -- Department of Chemistry
University of California, Irvine, CA 92697 USA

Lloyd M. Smith -- Department of Chemistry
University of Wisconsin, Madison, WI 53706 USA

Anne E. Condon -- Department of Computer Science
University of British Columbia, Vancouver, B.C., V6T 1Z4 Canada

| Overview | Papers | Links | People |

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Project Overview

This research project is aimed at the development and characterization of complex mixtures of DNA molecules attached to surfaces. The attachment chemistry, hybridization chemistry and enzymatic activity of the adsorbed DNA molecules will be characterized by a variety of spectroscopic and biochemical methods, and subsequently optimized for use in (i) the manipulation of DNA sequences in molecular computing strategies and (ii) the high density storage and retrieval of information by DNA hybridization chemistry. More...

A List of Our DNA Computing Papers:

• Ming Li, Hye Jin Lee, Ann E. Condon and Robert M. Corn,
  "A DNA Word Design Strategy for Creating Sets of Non-Interacting Oligonucleotides for DNA Microarrays,"
  Langmuir, 73 805-812 (2002).
  
  
• Emily A. Smith, Matt J. Wanat, Yufei Cheng, Sergio V. P. Barreira, Anthony G. Frutos and Robert M. Corn,
  "Formation, Spectroscopic Characterization and Application of Sulfhydryl-Terminated Alkanethiol Monolayers for the Chemical Attachment of DNA onto Gold Surfaces,"
  Langmuir, 17 2502-2507 (2001).
  
  
• Liman Wang, Qinghua Liu, Robert M. Corn, Anne E. Condon and Lloyd M. Smith,
  "Multiple Word DNA Computing on Surfaces"
  J. Am. Chem. Soc., 122 7435-7440 (2000).
  
  
• Qinghua Liu, Liman Wang, Anthony G. Frutos, Anne E. Condon, Robert M. Corn, and Lloyd M. Smith,
  "DNA Computing on Surfaces,"
  Nature, 403 175-179 (2000).
  
  
• "Reversible Protection and Reactive Patterning of Amine and Hydroxyl-Terminated Self-Assembled Monolayers on Gold Surfaces for the Fabrication of Biopolymer Arrays,"
  Anthony G. Frutos, Jennifer M. Brockman and Robert M. Corn,
  Langmuir, 16 2192-2197 (2000).
  
  
• "A Multi-Step Chemical Modification Procedure to Create DNA Arrays on Gold Surfaces for the Study of Protein-DNA Interactions with Surface Plasmon Resonance Imaging,"
  Jennifer M. Brockman, Anthony G. Frutos and Robert M. Corn,
  J. Am. Chem. Soc., 121 8044-8051 (1999).
  
  
• "Enzymatic Ligation Reactions of DNA "Words" on Surfaces for DNA Computing,"
  Anthony G. Frutos, Lloyd M. Smith, and Robert M. Corn,
  J. Am. Chem. Soc., 120 10277 (1998).
  
  
• "Demonstration of a Word Design Strategy for DNA Computing on Surfaces,"
  Anthony G. Frutos, Qinghua Liu, Andrew J. Thiel, Anne Marie W. Sanner,
  Anne E. Condon, Lloyd M. Smith, and Robert M. Corn,
  Nucleic Acids Research, 25 4748 (1997).

If you would like a reprint of one of these papers (most can now be emailed to you in pdf format), please email your request along with your name and mailing address to us at: yli6@uci.edu

Additional preprints of our papers on DNA computing that are available in PDF versions:

• "Reducing Errors in DNA Computing by Appropriate Word Design,"
  Jesse M. Gray, Tony G. Frutos, A. Michael Berman, Anne E. Condon, Max G. Lagally, Lloyd M. Smith and Robert M. Corn,
  preprint. PDF Version or Text Version
  
  
• "On Combinatorial Word Design,"
  Amit Maranthe, Anne E. Condon, Robert M. Corn,
  DIMACS Series in Discrete Mathematics and Theoretical Computer Science, 54 75-90 (2000).
  PDF Version

Related Links:

• A well-written article on DNA computing recently appeared in The Chronicle of Higher Education.
  Click here for a picture of the PIs taken from the article.
  
  
• Another article on DNA computing recently appeared in The Milwaukee Journal Sentinel.
  Click here for a picture of Tony taken from the article.
  
  
• Erik Winfree's Home Page.
  
  
• John Reif's Home Page.

If You Want To Learn More, Please Contact:

• Prof. Robert M. Corn
  Department of Chemistry
  University of California, Irvine
  Irvine, CA 92697
  rcorn@uci.edu



• Prof. Anne E. Condon
  Department of Computer Science
  University of British Columbia
  Vancouver, B.C., V6T 1Z4 Canada
  condon@cs.ubc.ca



• Prof. Lloyd M. Smith
  Department of Chemistry
  University of Wisconsin
  1101 University Ave.
  Madison, WI 53706-1396
  smith@chem.wisc.edu

DNA image obtained from: www.imb-jena.de